Chris from playon support just confirmed to me via email any android device running 2.2 and above and is compatible with adobe flash will work.
the Xoom will be compatible.
Originally Posted by Mitchrapp
PlayOn is a great thing to use. Been using it for 2 years now. But now there is an android app, hopefully it works on the Xoom well, I wouldn't be too worried. This device looks sweets as hell. Can't wait.