Hardware Video, Microphone, Camera, and USB file transfers have been well known for a while now. I thought Dalingrin found a resolution for TiBU but it's possible that it broke again.
Personally I've seen one reboot on my TP since loading the latest nightly. Since then it seems to have settled down and is fairly stable. Haven't run into any insurmountable issues yet... I figure I'll just keep doing what I'm doing until the next nightly is released. And then install that and start over again...
Edit: Apparently I spoke too soon!