Multiple users isn't a huge pain and we ended up just working with it; for instance, you can put a widget for each individual email account on your home screen, but the email app they both open is a single app. So if my wife opens her email, then some time later I open mine, if I press the 'back' button enough times it will take me to her email account. Not a huge problem but a little bit annoying.
Also, bookmarks: if I add mine and she adds hers it becomes a mess, so generally she uses the stock browser and I use Chrome.
Fortunately there's not much cross-over in the apps we use: I have a DropBox account but she doesn't and she uses FaceBook but I don't, so we can set those apps up to use my/her accounts separately without causing hassle.