Originally Posted by 9to5cynic
How does that 2nd mode work. I was thinking I'd save some for the play through with the siren. Maybe not now
For each character you beat the game with, you will unlock TVHM. It is basically a much more difficult playthrough of the 1st. The loot becomes a million miles better than anything you would ever find in the 1st playthrough as well. Let me put it like this, I had a legendary (orange) pistol that I replaced with a green about 5 minutes into TVHM mode.