I had several launchers on my Galaxy Nexus, but when I began moving apps over to the Note II, I cleaned house. Nova is the only one that made the cut.
As soon as it was installed, I switched to it to see if I'd lose any functionality. The easiest check was to simply remove the sPen. Yep- the sPen menus no longer come up upon removal of the pen. I went right back to TouchWiz.
I may play with it more at some point, but I haven't even had time to get rid of some of the tackier parts of the out-of-the-box functionality yet. Ultimately, I'd like to see a Nova add-on that re-enables the contextual sPen menus, because I do much prefer the simplicity of Nova over TouchWiz.