I know much of the complaints/quirks of the HTC ONE relate to tasks involved in Sense 5: blinkfeed, app drawer, moving apps to the home screen, from the dock, etc...
Is anyone actually going to stick with Sense 5 or are we all running Nova/Apex/GO launchers?
"Ain't nobody got time for that" persistent power save mode in the notification shade either, so I know I'll be running a custom ROM as well.
The hardware and camera features are the big hit of this phone. Pair it with a "better" launcher and even a custom ROM and this phone is damn near perfect.