I've been using the ONE since Saturday, almost nonstop. I previously had the onex+, so I'm pretty familiar with Sense. I like the camera. My wife has the SG3, and she's already jealous of the highlight reels in the gallery. Zoes are very cool! We have a 15 month old so the camera features are great for me. I agree with others that removing icons from the dock is a bit cumbersome, but once ya figure it out you're fine. I see HTC changing that system. The onex+ was easier to add widgets, icons to the homescreen.
Obviously fit and finish are incredible on the phone. The screen is awesome... Blinkfeed needs more options on feeds to display. Hopefully HTC allows us to remove Facebook from the gallery soon.