Originally Posted by Spewy
There is another fix on the xda site without the need to install another ROM.
"for those of you who are experiencing irresponsive back/home buttons you could try this below:
go to settings -> language&keyboard ->HTC sense input -> advanced -> calibration tool
When you're calibrating the keyboard, press the keys very lightly, after you're done you should have a better back/home key response."
worked for me.
Credit to mingtaoh
This does seem to help you the keys is to touch VERY VERY VERY LIGHTLY, that is crucial so far an hour into it so far so good. I will update.