Of course, it all depends on what you want to do with your phone. I think I'm mostly non-biased... I had the HTC hero, then 3d, then EVO LTE. I love HTC, but I hate to get TOO attached to anything like that, so I sprung for the S4. So far I love it. You'll notice it's different, but not that different.
Everything about it is better than the EVO LTE, but so would everything on the One.
Ever since I got my wife the Nexus 7, I've been a stock Android fanboy, so I use Holo Launcher HD. I like it better than Touch Wiz or Sense.
If you have specific questions, PM me or reply here.