please give more info
are you rooted?
using a launcher?
how much memory is on board? (tip: if you dont know, look in storage tab)
how long have you had the device? did it happen on day one?
used/refurbished device? or purchased brand new?
do you have the latest android update?
do you have any programs that alter the look of the home screen or widgets?
can you reproduce the problem art will? or is it random? how do you resolve it when it does happen?