I don't see why not. My go to launcher has been Nova but I've not installed it on the Tab Z yet. I think you'll be pleased with the Z after using Touchwiz.
Previous Phones: HTC Google G1, HTC Hero, Nexus One, Nexus S, HTC Desire HD, Samsung Galaxy SII, HTC Sensation, Galaxy Nexus, HTC One X, Nexus 4, HTC One
Previous Tablets: Motorola Xoom, Nexus 7.
Current: Nexus 5, Sony Tablet Z LTE.