I don't see why not. My go to launcher has been Nova but I've not installed it on the Tab Z yet. I think you'll be pleased with the Z after using Touchwiz.
Previous Phones: HTC Google G1, HTC Hero, Nexus One, Nexus S, HTC Desire HD, Samsung Galaxy SII, HTC Sensation, Galaxy Nexus, HTC One X, Nexus 4, HTC One, Nexus 5, Sony Xperia Z2, Nexus 5.
Previous Tablets: Motorola Xoom, Nexus 7.
Current: Nexus 5, Sony Tablet Z LTE.