I'm pleased and transition from original Incredible took only a short time. I'm amazed by the 4G speed except for the times it doesn't respond at all, which is just occasionally.
A couple of issues:
I do miss the dedicated search button at the bottom. I had grown accustomed to a quick press for search and a long press for voice search. I now have to surrender space on the home screen for the Google Search widget.
I also miss the dedicated Menu button, but that's more of an Android 3/4 thing. It sure was nice for getting into Android settings though.
Power button and volume buttons are recessed so much they are tricky to press. Volume buttons are now on the right side. Some may prefer, but I hold phone in left hand and my thumb was naturally positioned for volume on original Incredible. On the other side, I certainly don't accidentally press volume anymore.
Higher resolution screen leads to smaller text and icons. On the positive, it's a beautiful, bright display.
Even after inserting an SD card, you can't move apps there. This may eventually be a problem. The battery is removable and can be replaced. I'll probably move to a Seidio extended, same size battery when available as I always used these in the OG Incredible. Battery life is okay -- have to take some steps for all-day use. I think most 4G phones have this issue.