I'm using my own custom scene currently..
On the main page, I have the clock widget that has the weather on it, a folder for my most-used Apps, a folder for my most-used Games, and then at the bottom row I've got People, Browser, Camera, and Voicemail.
One page to the right is my full-page email widget, then the next page to the right is the full-page messages widget, then the last page to the right is the full-page picture album widget.
One page to the left of my home page is the People widget setup with all my most-used contacts, then the next page to the left has my half-page facebook widget on top and my half-page music widget on the bottom, then the last page to the left has my full-page bookmarks widget.
I'm also using the FlyScreen replacement lock screen to display my text messages, calendar, and facebook updates. I emailed the FlyScreen team to see if they are going to be adding an email widget. I'd love to be able to see my emails on my lock screen.
I'd say I'm using my Hero to it's full extent, lol.