Sure, some roms have different tweaks than others. If you want something clean and similar to the stock rom, go with TommyTomatoe's Evo Classic rom. Or you could even download his Senseless version that just came out today.
Something like MikG has an upgraded version of Sense with a bunch of tweaks built in. You get into Sense 3.0 and above and it has stuff like Carousel built in, or even Dre Beats, but I don't think it's 100% functional yet.
Then there is AOSP stuff if you are bored with Sense. Anything with a CM7 base (CM7, deck's, salvagemod, etc) have a built in theme chooser which can drastically change the look of your rom. Or for the ultimate experience in theming, there is MIUI. It's just a matter of flashing different stuff until you find your own personal sweet spot.
And even then, most of us still keep flashing different things. I can almost never stay on any single setup for longer than a week.