Here's my current setup. I've had the phone for a while now, but this thread inspired me to finally customize a bit. This is LauncherPro on stock VZW 2.2 w/ Sense, and Apps Organizer to group apps together.
Far left: Nothing special. Just the LauncherPro friend widget.
Left: Apps Organizer groups.
Top row: Internet, Navigation, Entertainment, Media.
Bottom row: Shopping, Creativity, Games, Comics.
Center: Small Beautiful Widgets Home with DirtyPaper clock & weather theme.
Top row (apps): Dolphin HD, Maps, Gallery, Camera.
Bottom row (Apps Organizer groups): Communication, Calendars/to dos/notes, Information, Utilities.
Right: Remember the Milk widget, News widget, Extended Controls widget.
Far right: LaucherPro calendar widget.