I do bi-weekly Titanium Backup backups, so I'm not too worried about it. My big thing is that literally all but one item on my three home screens are widgets (I use multicon to preserve screen real estate). I recently switched to GO Launcher as a test run, but I know when I would restore Launcher Pro, it would give widget errors, forcing me to remove the widgets and then put them back up. That's not even a big hassle, but an annoyance.
I was just curious if anyone had anything like battery life or performance improvements. Just something that would make me a little less lazy.