I updated to 5.11.401.10 with Sense 6.0 a few days ago. The only problem I've experienced is a completely new set of sounds which resulted, in some cases eg stock email, defaulting to silent which meant going through all my sound/notification settings re-enabling and selecting new sounds. A pain in the proverbial but easily fixable if a little time consuming.
I certainly haven't experienced any of the obviously more serious problems listed by others, although I have had minor problems after earlier updates. I got into the habit of doing a 'wipe cache partition' after an update which has been successful and may be worth trying before a full reset - wipe cache partition does not affect any data or settings. In fact some advocate doing it on a regular basis to clean things up.
Wipe Cache Partition
Before booting into Recovery, ensure that fast boot has been turned off:
1. Tap Menu
2. Tap Settings
3. Tap Power
4. Uncheck the box for Fast boot.
Once fast boot has been turned off, reboot into Recovery to wipe cache partition:
1. Power off the device
2. While holding down the Volume Down button, press the Power button. The device will boot into the bootloader which is a white screen with 3 Androids at the bottom screen.
3. Using the Volume Down button, select RECOVERY
4. Press the Power button to select the option. Device will reboot into a black screen with a red exclamation mark in a red triangle atop a device.
5. Press Volume Up and Power button to get into the Recovery menu.
6. Using Volume Down button, highlight the Wipe cache partition option.
NOTE: Be sure that Wipe cache partition is highlighted. Do not choose Wipe data/factory reset as this will result in loss of data!
7. Press the Power button to select the option
8. When the process, is complete, ensure that Reboot system now option is highlighted.
9. Press the Power button to select the option and reboot the device into the OS.
Up to now, I like the Sense 6.0 changes! even the time/weather widget changing from white to black (day/night) - quite entertaining - don't you think??