Try clearing TouchWiz Home's cache (if you can get into the system settings still) then rebooting the phone. With any luck it's just that the launcher crashed and its settings haven't been lost, in which case your desktop might return to normal. If that isn't enough you could boot into recovery and clear the system cache (not the same thing as a factory reset) - that would be a long shot, but isn't a bad idea generally after an update.
If you it's the same after a reboot let us know. The next thing to try (if you can get into settings) would be to clear data for TouchWiz Home, which will erase your desktop setup but might help if the problem is an incompatibility between its current settings and a new version of the app.
If you can't get a desktop and app drawer back after that then assuming you don't want to do a factory reset the next thing I'd try is to install a different launcher. Go to play.google.com using a web browser on any computer, sign in to your google account, pick a launcher (e.g. Nova) and select "install". As long as your phone has an internet connection the launcher will install, and once it's done that press the "home" button - it should ask you which app you want to complete the action with, after which you can select the new launcher and you will have a desktop/app drawer again. Then you can set it up so you can use your phone, either sticking with the new launcher or at least giving you something you can use while we figure out what's wrong with the old one.