Titanium Backup is its 'Freeze' and 'Defrost' features which can be really useful. With some of the bloatware removal apps if you delete some app you later want back, or some app tied to an important system-related process, that could be a problem. If you use TB to freeze an app, it stops that app from working and removes its icon from your App menu. If you later want to restore said app just defrost it and it's usable again (and its icon is back in your App menu).
If storage space is an issue you might be better off deleting unwanted apps, but using TB instead to freeze/defrost apps is a good way to free up system resources but still have a way to restore a particular app that you might need or want later.