I'd vacuum it before I took the chance of blowing it further into the device.

 

You must be OCD like me when it comes to your expensive electronics. To clean in-between the screen and bevel, I've been using post-in notes to lift the lint and other gunk out of there. They are thin enough to fit in that space, and if you want you can use the part of the note that is sticky to help you lift out lint more easily.

I'm still looking for good ideas to clean out the speaker though. I used a q-tip dipped in alcohol the other day and that worked decently. I can see the speaker getting really dirty if it isn't cleaned out semi-regularly.