No real difference. If you never travel outside of the US, you can choose LTE/CDMA. If you go anywhere else, you can manually change it or leave it as is (in global mode).
Since I never go outside the U.S., I choose to change mine to LTE/CDMA. I don't KNOW this, but it seems to me that turning off the one radio could help battery life (one less radio it hunts through when searching for a signal). Again, I have no facts to back up that thought, it's just the way I set mine.
If its set to GLOBAL it has every radio in the phone on, I think theres 5 in total but if its set to LTE/CDMA it will only have 2 on at a time LTE/1x or if no LTE is available EvDo/1x. So it'll help battery life.
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