I can't vouch to the safety of anything else, but here are the programs I removed with no problems:
CarHome
Google+
Guided Tours
M Studio
Metro411
MetroPCS Easy WiFi
MyMetro (Safe to remove, but I kept for bill payment conveniences)
MetroWEB
Movies
Pocket Express
Sportacular
Total Protection
Messaging (I use Handcent SMS)
I'm absolutely positive that there's more bloatware that can be safely removed, so if anyone wants to add to this list... we could finally make a sticky maybe?