If you don't want to deal with the technical complexities of installing RUU manually, then yes you can wipe after the OTA update. However, I have absolutely no desire to do so unless I have serious issues after the update. For the same reason I still have XP - when I build a new computer later this year I'll install Windows 7. I have no interest in spending days reinstalling all my applications, games, updates, patches, data, drivers, settings, etc. etc. until necessary. So, no it's generally not necessary to wipe after the OTA if everything is working fine.
One other comment - are we 100% certain the leaked RUU is identical to the OTA version?
Root, Run Titanium backup, install RUU, and use Titanium to restore everything (apps, settings, etc). Done. No reinstalling.
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