I literally spent 8 hours customizing Beautiful Widgets, WidgetLocker, and LauncherPro to perfection yesterday, only to uninstall them at the end of a long night because my phone lagged so much. With WidgetLocker, I couldn't use the stock HTC slider because it would lag like crazy upon unlock and flash between the lock screen and home screen. LauncherPro stuttered so much trying to switch between home screens, it was like I was trying to fight against the elasticity. It also lagged in menus and settings and was just generally an unpleasant experience. I liked Beautiful Widgets, but there was no reason to keep it installed without LP, seeing as I like the stock weather/clock the best.
TL;DR: Absolutely loved the way my phone looked, but not about to trade functionality for appearance. Dinc was just too slow.