well, you dont even need to uninstall; you just make it so that Sense becomes your "home Screen"..and, when you go back to Sense, everything looks "HTC" like..
If you go back to ADW or LP again, your screens go back to the "default" ADW or LaunchPro, and you have to re-configure them all over again..sort of a pain, but it only takes about 30 minutes to get everything back to how it was
I keep a sheet of paper with my screen layouts on them, incase I do go back and forth..
If you could put the HTC Homescreen in Landscsape, I would stick with it, but since you cant, its always gonna be an alternative launcher for me..