I don't see why it wouldn't work. The skins aren't that thick. I wouldn't use the second screen cover though.

 

the otter box doesn't have a built in "skin" so yes this would work. I have the otter box on my phone and it is a great case.

 

should even work if you have the whole phone protected w/ either phanton or invisible shield. I have the phanton skinz screen cover.

 

I have a case from VZW and it fits very tight on my Droid with an invisible shield. The protector on the screens border is especially snug, and it even damages the invisible shield slightly. I would recommend keeping only the invisible shield, don't worry about the otterbox (unless you are especially clumsy). I also have a Zagg Leather Skin on my phone too, and it is pretty sweet. Hope this helps.

 

Love the otterbox. I like the fact that it has rubber covers that protect the inputs. It keeps pocket lint from getting inside it