I'm using the nightly builds from the Cyanogenmod website.
After a few weeks, here's what I've noticed:
1) Device freezes. This has been happening on previous versions, too...not unique to CM10. It just won't come out of standby sometimes, without a hard reset.
2) Wifi. It can handle basic, quick tasks with no problem. But on a large download (like the next nightly build), the wireless connection will just drop, for no reason. I'm the sole user of a 75-megabit fiber connection, in point-blank range of the router. So, it's definitely something within the device, and nothing related to signal quality or network overload.
3) GPS. Unlike my initial experience, Google Maps can now receive GPS data correctly, but it seems like it might still be hit-or-miss with some other GPS-dependent apps.
Overall, I'm ready to suggest it for installation. Although it's still in nightly builds, it seems stable enough to use regularly.