Interference related to hands varies by how many towers are near you, the position of the phone in 3d space, and the placement of the antenna.
IF you have 1 tower in the area and you move the phone so the screen is facing that tower and cover the back of the phone, that will drop the signal strength on any phone, the 4.3 inch screen blocks most radio signals. In those cases, if you rotate the phone 180 degrees so the back of the tower is facing the phone, you will see only a slight drop in signal.
If you are in a verizon and sprint cross over area that has been miss managed, or you are near a wireless broadcast system, that is using, often illegally, like a PA, you can cup the phones back, which will increase the signal strength.
This will happen with all phones, depending on the tower coverage, phones locations and physical bodies.
However, this is not the same has the iphone 4 problem which was simply shorting out the radio by physical touch.