Hi my wife have a HTC desire and the screen get some water and is working a letilebit wath I can do for that
Welcome to the AndroidForum, tyfon.
Sorry to hear about your issues with your wife's phone.
The best advice that I've read here multiple times before it to:
1. Remove the battery from the device (water and electricity are a bad combination)
2. Get a Ziplock bag or an air-tight container and fill it with dry rice (be sure its dry, LOL)
3. Place the phone in the bag or container and seal it up for a
"while" (I've heard timeframes from 8 hours to multiple days--the longer the better in order to wick-away the moisture). You could also replace the dry rice to ensure that you are wicking away more moisture.
4. After you have dried-out the phone as best you can, re-insert the battery and try to start it up.
I've read many stories here of folks that had phones with water damage (some went through an entire wash cycle and came out completely fine if you can believe it). Your mileage will certainly vary here, so give the rice a try.
Good luck and you can always search for more advice and suggestions here in your phone's home forum:
HTC Desire - Android Forums
Cheers!