Once I long-press on the screen, the touch-screen becomes non-responsive. By non-responsive, I mean that I can not swipe to change screens, access any apps on the screen, or access the functions associated with the soft-keys next to the home button.

However, if I press the screen on/off button on the side, then responsiveness is restored, at least until I long-press again.

I am running Nova Launcher, but the desktop lock is off. I've updated Nova Launcher just to make sure that it is not causing the problem. I am rooted.

At this point I'm clueless -- anyone have any idea on this one?