This is significant because Sense UI overlay virtually indicates that you will not be getting OS updates as quickly or immediately as those running a purer Google experience. While Google won't designate the DROID as a 100% pure Google phone (the Nexus One is), it is the least encumbered Android phone on the market with the hardware specs to handle the next and latest updates.
Sense UI is a huge advantage for a device if the playing field were level (i.e. everyone sporting Android 2.1). But when the OS updates to 2.2 or 3.x, will the Incredible (and other Sense phones) update as quickly as non-Sense phones? The precedence is that no, it will not update because Sense needs to be reconfigured for new features.
One of the things rumored to come out with 2.2 is this whole Core + apps management that will curb fragmentation. Since Sense essentially INTEGRATES all the native apps, when 2.2 drops, how will it differentiate what is native and what is market, since all components will now be located on the market? These are the limitations I see with the Incredible, and why I consider it noteworthy that VZW isn't picking up the N1.
What this means is that, if there is an N1 on the VZW network, why would you EVER buy another phone or device? By having a phone like the DROID and Incredible locked to the VZW, they ultimately have the deciding authority on who and when someone gets an official update, if they ever do. And hey, if you don't want to root to get it unofficially, guess what? You can buy this new phone that VZW is offering! That's why VZ's business model will ALWAYS be more profitable and sustainable than Google's experiment at selling phones.