For my two cents, upgrading to a class 6 card made a world of difference.
The music player and browsing photos are a little snappier, but not a ton--I definitely see some increase in the read speed of this card, but there's clearly a bigger bump in write speed.
Where I see a lot of difference is the camera (almost zero lag after taking picture/video, it's ready to snap again almost immediately), and sync time is a lot faster... I use Salling Media Sync, which tells you the speed it's writing data to the card. With the class 2 I was getting speeds around 2-3 Mbytes/sec, maxing out at just under 4. With the new card, it's consistently between 6-7, and it crept up to 9.X mBytes/sec for a little while. It takes almost no time at all to load huge files or a ton of music on this thing anymore. Saving files from the web is faster, if you use Dolphin and cache on the SD card, the browser responds quicker, etc. It's not system-wide, but there's improvements in a lot of areas.
You can replace your stock 8 gig card with a class 6 of the same size for about $20, or about $40-$50 for a 16 gig. Yes, it's an added expenditure, but remember that this isn't like buying an Eris-specific battery or case... if/when you move on to your next upgraded phone, chances are you can take the SD card with you. I'd highly recommend this upgrade, honestly.