It's my understanding that each Launcher/Home screen replacement is built on its own spacing system. The Note is standard 5x5, but some launchers let you change that in their settings options.

Some launchers also let you resize widgets or applications to fill the gaps, but if you're trying to fill a 2x1 gap with a 1x1 app it's not going to work. Some times you just have to customize based on the grid

 

i'm guessing you want to cram as many icons as possible on one screen? try multicon...