The build on this thing is unreal. The screen is also incredible. I'm sending this from my 6 month old Macbook Pro. This is the first I've used the computer since getting the DNA and I immediately noticed how much worse. This screen is compared to the DNA. I've also had the phone unplugged since 7am and using it heavily since around 10am. Battery just dropped below 50%. I'm very pleased with that. That was a big concern as I am coming from the iP4.
HTC did a great job putting such a large screen in a small package (considering the size of the screen), but I'm still having reservations on the size of the device. I used the iP4 as my main music source, particularly in the gym and I'm not confident this will be good for that use. I really, really want to get used to the DNA because the screen is amazing, the build quality is top notch, and it runs buttery smooth. If you aren't concerned about size (insert joke), I would absolutely recommend this phone. FYI, I used to have the Droid X so I am familiar with the Android ecosystem.