It might be possible, but only info I found in a google search indicates some registry edits are necessary along with a driver file. A simpler (and slicker) set-up might be to use Wii remotes through your tablet's bluetooth. I'm doing this on my Xoom as I happen to have possession of my sister's Wii at the moment. However, its limitation is that the standard wii remote isn't going to be set up well for anything but the original NES system. You can add the classic controller attachment but that uses a wired connection to a wii remote. The other option is to use Datel's Retro controller for the Wii, which will provide a direct wireless connection to the tablet through the bluetooth. I actually just ordered a couple for myself in fact. All you need to get it running is the wiimote control app which you can find in the market. Its working fine with Nesoid Lite. A big advantage to a wii remote is that you can use it without the dock.