I have small hands for a man and have no problem with the size, weight, or thinkness. I came from an OG Droid so it took some getting used to for the size. I use swype so the only issue I have is that I don't use it when the phone is in landscape mode, because it makes the screen to large to trace one handedly. However, I don't really need the phone to be in landscape mode to type anyway since it's large enough vertically to type effectively with swype or not.
I keep a Seidio Active case on my phone which adds a little thickness and weight. It's not so bad but the OG Droid probably weighed about the same so I'm probably a little biased becuase I didn't come directly from a lighter phone.
When I travel I bring the ext. battery which adds even more thickness but I go caseless when I'm using it. The phone with the standard battery and with my case are probably about the same so I never really notice a considerable difference.
All in all, it's a good phone. Not perfect (battery life), but very good (camera, screen res, audio, width for a 4.3" phone).